3.4+DNA+replication

3 Chemistry of Life - 3.1 Chemical elements and water - 3.2 Carbohydrates, proteins and lipids - 3.3 DNA structure - 3.4 DNA replication - 3.5 Transcription and translation - 3.6 Enzymes - 3.7 Cell respiration - 3.8 Photosynthesis - Biochemistry Labs - DNA Labs

3.4 //(and 7.2)// DNA replication
// N.B. This topic links to 7.2 DNA Replication which HL students will be studying in conjunction with this topic. This page contains both Core and AHL content. AHL specific content is written in italics //


 * Assessment statements** (IBO notes added to some points to clearly indicate what needs to be understood and what does not)
 * 3.4.1 || Explain DNA replication in terms of unwinding the double helix and separation of the strands by helicase, followed by formation of the new complementary strands by DNA polymerase. It is not necessary to mention that there is more than one DNA polymerase. ||
 * 3.4.2 || Explain the significance of complementary base pairing in the conservation of the base sequence of DNA. ||
 * 3.4.3 || State that DNA replication is semi-conservative. ||


 * //7.2.1// || //State that DNA replication occurs in a 5' -> 3' direction. The 5’ end of the free DNA nucleotide is added to the 3’ end of the chain of nucleotides that is already synthesized.// ||
 * //7.2.2// || //Explain the process of DNA replication in prokaryotes, including the role of enzymes (helicase, DNA polymerase, RNA primase and DNA ligase), Okazaki fragments and deoxynucleoside triphosphates. The explanation of Okazaki fragments in relation to the direction of DNA polymerase III action is required. DNA polymerase III adds nucleotides in the 5' -> 3' direction. DNA polymerase I excises the RNA primers and replaces them with DNA.// ||
 * //7.2.3// || //State that DNA replication is initiated at many points in eukaryotic chromosomes.// ||

DNA structure and replication by Hank of the Sci Show media type="custom" key="24681108"
 * Starter**

An alternative set of notes from i-Biology can be found here __ Core content only __ media type="custom" key="23828634" __ //Core and AHL together// __ media type="custom" key="23828582"
 * Workbooks and Worksheets **

Steven Taylor ( [|i-Biology] ) has a great presentation to view and take notes from before starting your notebook media type="custom" key="23828548"
 * Presentations and tutorials **

Jason De Nys also has a very good presentation to use for note development media type="custom" key="24507812"

Very good DP Bio specific video tutorials from [|C4B] 3.4.1 DNA replication media type="custom" key="23828638" 3.4.3 Semi-conservative replication media type="custom" key="23828640"

HL students can use the teaching and visualization animation from St Olaf to gain an overview of DNA Replication

Use [|click4biology] to review and complete your notes on [|3.4 DNA Replication] and additionally for // HL students [|7.1 DNA Replication] //


 * Activities**

Learn about replication by [|making your own strands of DNA] using this interactive animation and tutorial


 * Useful Links **

====[|This lecture describes] //how we found out that DNA replicates, copies itself, those doing just standard level might find this difficult to follow//====
 * SL **

====[|DNA Replication]//is illustrated in this short video, it has slightly more detail than is needed for standard level, but shows the process clearly//====

====[|St. Olaf], Wiley, [|MCB Harvard] //and// [|John Kyrk] //all do good animations to show DNA Replication in detail – see which one you think is best//====
 * HL **

====//Review the// [|DNA Replication fork] //by McGraw and Hill before looking at// [|How bases are added]====